abstract：:The MEI-1/MEI-2 microtubule-severing complex, katanin, is required for oocyte meiotic spindle formation and function in C. elegans, but the microtubule-severing activity must be quickly downregulated so that it does not interfere with formation of the first mitotic spindle. Post-meiotic MEI-1 inactivation is accomplis...

journal_title：Developmental biology

authors： Johnson JL,Lu C,Raharjo E,McNally K,McNally FJ,Mains PE

更新日期：2009-06-15 00:00:00

abstract：:In the course of embryogenesis multicellular structures and organs are assembled from constituent cells. One structural component common to many organs is the tube, which consists most simply of a luminal space surrounded by a single layer of epithelial cells. The notochord of ascidian Ciona forms a tube consisting of...

journal_title：Developmental biology

authors： Dong B,Horie T,Denker E,Kusakabe T,Tsuda M,Smith WC,Jiang D

更新日期：2009-06-15 00:00:00

abstract：:Canonical Wnt signalling is known to be involved in the regulation of differentiation and proliferation in the context of endodermal organogenesis. Wnt mediated beta-catenin activation is understood to be modulated by secreted Frizzled-related proteins, such as XsFRP5, which is dynamically expressed in the prospective...

journal_title：Developmental biology

authors： Damianitsch K,Melchert J,Pieler T

更新日期：2009-05-15 00:00:00

abstract：:The current gene regulatory network (GRN) for the sea urchin embryo pertains to pregastrular specification functions in the endomesodermal territories. Here we extend gene regulatory network analysis to the adjacent oral and aboral ectoderm territories over the same period. A large fraction of the regulatory genes pre...

journal_title：Developmental biology

authors： Su YH,Li E,Geiss GK,Longabaugh WJ,Krämer A,Davidson EH

更新日期：2009-05-15 00:00:00

abstract：:Insulin-producing beta-cells are present as single cells or in small clusters distributed throughout the pancreas of the Xenopus laevis tadpole. During metamorphic climax when the exocrine pancreas dedifferentiates to progenitor cells, the beta-cells undergo two changes. Insulin mRNA is down regulated at the beginning...

journal_title：Developmental biology

authors： Mukhi S,Horb ME,Brown DD

更新日期：2009-04-15 00:00:00

abstract：:In Caenorhabditis elegans, Wnt signaling regulates many asymmetric cell divisions. During embryogenesis, the C. elegans Dishevelled (Dsh) homolog, DSH-2, regulates asymmetric neuroblast division of the ABpl/rpppa blast cell. Dsh is a key intracellular component of both beta-catenin dependent and beta-catenin independe...

journal_title：Developmental biology

authors： Hingwing K,Lee S,Nykilchuk L,Walston T,Hardin J,Hawkins N

更新日期：2009-04-15 00:00:00

abstract：:In mammals, two spatially and temporally distinct waves of fiber cell differentiation are crucial steps for normal lens development. In between these phases, an anterior growth zone forms in which progenitor cells migrate circumferentially, terminally exit the cell cycle and initiate differentiation at the lens equato...

journal_title：Developmental biology

authors： Le TT,Conley KW,Brown NL

更新日期：2009-04-01 00:00:00

abstract：:The formation of an anterior-posterior (AP) gradient of microtubules in Drosophila oocytes is essential for specification of the AP axis. Proper microtubule organization in the oocyte requires the function of serine/threonine kinase Par-1. The N1S isoform of Par-1 is enriched at the posterior cortex of the oocyte from...

journal_title：Developmental biology

authors： Tian AG,Deng WM

更新日期：2009-03-15 00:00:00

abstract：:Vertebrate neural tube formation involves two distinct morphogenetic events--convergent extension (CE) driven by mediolateral cell intercalation, and bending of the neural plate driven largely by cellular apical constriction. However, the cellular and molecular biomechanics of these processes are not understood. Here,...

journal_title：Developmental biology

authors： Rolo A,Skoglund P,Keller R

更新日期：2009-03-15 00:00:00

abstract：:Stable subdivision of Drosophila limbs into Anterior (A) and Posterior (P) compartments is a consequence of asymmetric signaling by Hedgehog (Hh) from P to A cells. The activity of the homeodomain protein Engrailed (En) in P cells has been reported to help to generate this asymmetry by inducing the expression of hedge...

journal_title：Developmental biology

authors： Bejarano F,Milán M

更新日期：2009-03-15 00:00:00

abstract：:Antenna structure varies widely among insects, in contrast to the well-conserved structure of legs. The adult capitate antenna of the red flour beetle, Tribolium castaneum, is composed of eleven articles, organized into four distinct morphological regions (scape, pedicel, funicle and club). Here, we report the use of ...

journal_title：Developmental biology

authors： Angelini DR,Kikuchi M,Jockusch EL

更新日期：2009-03-01 00:00:00

abstract：:Myf5 is a key myogenic determination factor, specifically present at sites of myogenesis. Surprisingly, during mouse development, this gene is also transcribed in restricted areas of the central nervous system, although the Myf5 protein is not detectable. We have investigated the regulation of Myf5 expression in the c...

journal_title：Developmental biology

authors： Daubas P,Crist CG,Bajard L,Relaix F,Pecnard E,Rocancourt D,Buckingham M

更新日期：2009-03-01 00:00:00

abstract：:The endoderm of C. elegans arises entirely from a single progenitor cell, the E blastomere, whose identity is specified by GATA type transcription factors, including END-1. In response to an inductive interaction mediated through Wnt/MAP kinase signaling pathways, POP-1, a Lef/Tcf-type transcription factor, restricts ...

journal_title：Developmental biology

authors： Witze ES,Field ED,Hunt DF,Rothman JH

更新日期：2009-03-01 00:00:00

abstract：:In most ascidians, metamorphosis of tadpole-like swimming larvae is accompanied by dynamic changes in their shape to form sessile adults. The mechanisms underlying ascidian metamorphosis have been debated for a long time. Although recent molecular studies have revealed the presence of various molecules involving in th...

journal_title：Developmental biology

authors： Nakayama-Ishimura A,Chambon JP,Horie T,Satoh N,Sasakura Y

更新日期：2009-02-15 00:00:00

abstract：:COUP-TFII (also known as Nr2f2), a member of the nuclear orphan receptor superfamily, is expressed in several regions of the central nervous system (CNS), including the ventral thalamus, hypothalamus, midbrain, pons, and spinal cord. To address the function of COUP-TFII in the CNS, we generated conditional COUP-TFII k...

journal_title：Developmental biology

authors： Kim BJ,Takamoto N,Yan J,Tsai SY,Tsai MJ

更新日期：2009-02-15 00:00:00

abstract：:Hair shafts are produced from stem cells located in the bulge. Our knowledge of the genetic pathways regulating cell fate acquisition in the immediate descendents of these stem cells, and fate maintenance in their committed progeny, is still incomplete. One pathway involved in fate maintenance within the hair matrix i...

journal_title：Developmental biology

authors： Cai J,Lee J,Kopan R,Ma L

更新日期：2009-02-15 00:00:00

abstract：:Cell-cell fusion is a fundamental cellular process that is essential for development as well as fertilization. Myoblast fusion to form multinucleated skeletal muscle myotubes is a well studied, yet incompletely understood example of cell-cell fusion that is essential for formation of contractile skeletal muscle tissue...

journal_title：Developmental biology

authors： Duan R,Gallagher PJ

更新日期：2009-01-15 00:00:00

abstract：:In vertebrates, the Müllerian duct elongates along the Wolffian duct, a mesonephric structure that is required for Müllerian duct formation. Recently, several genes required for initial Müllerian duct formation have been identified. However, the precise mechanism of Müllerian duct elongation remains to be elucidated. ...

journal_title：Developmental biology

authors： Fujino A,Arango NA,Zhan Y,Manganaro TF,Li X,MacLaughlin DT,Donahoe PK

更新日期：2009-01-15 00:00:00

abstract：:The Rho family of small GTPases has been implicated in many neurological disorders including mental retardation, but whether they are involved in primary microcephaly (microcephalia vera) is unknown. Here, we examine the role of Rac1 in mammalian neural progenitors and forebrain development by a conditional gene-targe...

journal_title：Developmental biology

authors： Chen L,Melendez J,Campbell K,Kuan CY,Zheng Y

更新日期：2009-01-01 00:00:00

abstract：:Distal-less 3 (DLX3) gene mutations are etiologic for Tricho-Dento-Osseous syndrome. To investigate the in vivo impact of mutant DLX3 on bone development, we established transgenic (TG) mice expressing the c.571_574delGGGG DLX-3 gene mutation (MT-DLX3) driven by a mouse 2.3 Col1A1 promoter. Microcomputed tomographic a...

journal_title：Developmental biology

authors： Choi SJ,Roodman GD,Feng JQ,Song IS,Amin K,Hart PS,Wright JT,Haruyama N,Hart TC

更新日期：2009-01-01 00:00:00

abstract：:We examined the structure, expression, and possible functions of a nanos homologue during gametogenesis and blastogenesis in the colonial ascidian Botryllus primigenus. An approximately 1.3-kb-long cDNA was cloned; it was termed BpNos since the deduced amino acid sequence (288 aa) contained 2 Nanos-like CCHC zinc fing...

journal_title：Developmental biology

authors： Sunanaga T,Satoh M,Kawamura K

更新日期：2008-12-01 00:00:00

abstract：:In mouse sex differentiation, SRY promotes Sertoli cell differentiation via SOX9 action, resulting in testis formation. SRY/SOX9 also initiates various testis-specific morphogenic events including glycogenesis in pre-Sertoli cells, suggesting the importance of glucose storage for certain SRY/SOX9-downstream events in ...

journal_title：Developmental biology

authors： Matoba S,Hiramatsu R,Kanai-Azuma M,Tsunekawa N,Harikae K,Kawakami H,Kurohmaru M,Kanai Y

更新日期：2008-12-01 00:00:00

abstract：:Mesodermal tissue with heart forming potential (cardiogenic mesoderm) is induced during gastrulation. This cardiogenic mesoderm later differentiates into heart muscle tissue (myocardium) and non-muscular heart tissue. Inhibition of Wnt/beta-catenin signaling is known to be required early for induction of cardiogenic m...

journal_title：Developmental biology

authors： Lavery DL,Martin J,Turnbull YD,Hoppler S

更新日期：2008-11-15 00:00:00

abstract：:All metazoan genomes encode multiple RAS GTPase activating proteins (RasGAPs) that negatively regulate the conserved RAS/MAPK signaling pathway. In mammals, several RasGAPs exhibit tumor suppressor activity by preventing excess RAS signal transduction. We have identified gap-3 as the to date missing Caenorhabditiseleg...

journal_title：Developmental biology

authors： Stetak A,Gutierrez P,Hajnal A

更新日期：2008-11-15 00:00:00

abstract：:The lens in the vertebrate eye has been shown to be critical for proper differentiation of the surrounding ocular tissues including the cornea, iris and ciliary body. In mice, previous investigators have assayed the consequences of molecular ablation of the lens. However, in these studies, lens ablation was initiated ...

journal_title：Developmental biology

authors： Zhang Y,Burgess D,Overbeek PA,Govindarajan V

更新日期：2008-11-01 00:00:00

abstract：:Sex-determination in Caenorhabditis elegans requires regulation of gene transcription and protein activity and stability. sel-10 encodes a WD40-repeat-containing F-box protein that likely mediates the ubiquitin-mediated degradation of important sex-determination factors. Loss of sel-10 results in a mild masculinizatio...

journal_title：Developmental biology

authors： Killian DJ,Harvey E,Johnson P,Otori M,Mitani S,Xue D

更新日期：2008-10-15 00:00:00

abstract：:The Xenopus helix-loop-helix transcription factor Hairy2 is essential for neural crest progenitor survival and maintains cells in a mitotic undifferentiated pre-neural crest state. However, its mode of action remains largely unknown. Here we show that a Hairy2 DNA-binding mutant is unable to promote cell survival and ...

journal_title：Developmental biology

authors： Nichane M,Ren X,Souopgui J,Bellefroid EJ

更新日期：2008-10-15 00:00:00

abstract：:Cdc42 and Rac1 Rho family GTPases, and their interacting protein IQGAP1 are the key regulators of cell polarity. We examined the role of Cdc42 and IQGAP1 in establishing the polarity of mouse oocyte and regulation of meiotic and mitotic divisions. We showed that Cdc42 was localized on the microtubules of meiotic and m...

journal_title：Developmental biology

authors： Bielak-Zmijewska A,Kolano A,Szczepanska K,Maleszewski M,Borsuk E

更新日期：2008-10-01 00:00:00

abstract：:The vertebrate cranial base is a complex structure composed of bone, cartilage and other connective tissues underlying the brain; it is intimately connected with development of the face and cranial vault. Despite its central importance in craniofacial development, morphogenesis and tissue origins of the cranial base h...

journal_title：Developmental biology

authors： McBratney-Owen B,Iseki S,Bamforth SD,Olsen BR,Morriss-Kay GM

更新日期：2008-10-01 00:00:00

abstract：:The inner ear, the sensory organ responsible for hearing and balance, contains specialized sensory and non-sensory epithelia arranged in a highly complex three-dimensional structure. To achieve this complexity, a tight coordination between morphogenesis and cell fate specification is essential during otic development....

journal_title：Developmental biology

authors： Vázquez-Echeverría C,Dominguez-Frutos E,Charnay P,Schimmang T,Pujades C

更新日期：2008-10-01 00:00:00

abstract：:Cardiac troponin T (cTnT) is a component of the troponin (Tn) complex in cardiac myocytes, and plays a regulatory role in cardiac muscle contraction by anchoring two other Tn components, troponin I (TnI) and troponin C, to tropomyosin (Tm) on the thin filaments. In order to determine the in vivo function of cTnT, we c...

journal_title：Developmental biology

authors： Nishii K,Morimoto S,Minakami R,Miyano Y,Hashizume K,Ohta M,Zhan DY,Lu QW,Shibata Y

更新日期：2008-10-01 00:00:00

abstract：:GATA4, a transcription factor expressed in the proximal small intestine but not in the distal ileum, maintains proximal-distal distinctions by multiple processes involving gene repression, gene activation, and cell fate determination. Friend of GATA (FOG) is an evolutionarily conserved family of cofactors whose member...

journal_title：Developmental biology

authors： Beuling E,Bosse T,aan de Kerk DJ,Piaseckyj CM,Fujiwara Y,Katz SG,Orkin SH,Grand RJ,Krasinski SD

更新日期：2008-10-01 00:00:00

abstract：:Mammalian eggs remain arrested at metaphase of the second meiotic division (metII) for an indeterminate time before fertilization. During this period, which can last several hours, the continued attachment of sister chromatids is thought to be achieved by inhibition of the protease separase. Separase is known to be in...

journal_title：Developmental biology

authors： Nabti I,Reis A,Levasseur M,Stemmann O,Jones KT

更新日期：2008-09-15 00:00:00

abstract：:Developmental boundaries ensure that cells fated to participate in a particular structure are brought together or maintained at the appropriate locale within developing embryos. Parasegment grooves mark the position of boundaries that separate every segment of the Drosophila embryo into anterior and posterior compartm...

journal_title：Developmental biology

authors： Larsen C,Bardet PL,Vincent JP,Alexandre C

更新日期：2008-09-15 00:00:00

abstract：:Vertebrate heart development requires specification of cardiac precursor cells, migration of cardiac progenitors as well as coordinated cell movements during looping and septation. DM-GRASP/ALCAM/CD166 is a member of the neuronal immunoglobulin domain superfamily of cell adhesion molecules and was recently suggested t...

journal_title：Developmental biology

authors： Gessert S,Maurus D,Brade T,Walther P,Pandur P,Kühl M

更新日期：2008-09-01 00:00:00

abstract：:The mammillary body, a ventral specialization of the caudal hypothalamus, lies close to the transition between epichordal and prechordal parts of the forebrain (Puelles and Rubenstein, 2003). This report examines its presumed causal connection with either prechordal or notochordal mesodermal induction, as well as the ...

journal_title：Developmental biology

authors： García-Calero E,Fernández-Garre P,Martínez S,Puelles L

更新日期：2008-08-15 00:00:00

abstract：:Notch signaling is involved in a large range of developmental processes, and has been functionally implicated in body plan segmentation in two of the three diverse segmented taxa, the vertebrates and arthropods. Here we investigate expression of Notch, Delta, and hes gene homologues during larval and juvenile developm...

journal_title：Developmental biology

authors： Thamm K,Seaver EC

更新日期：2008-08-01 00:00:00

abstract：:Receptor protein tyrosine phosphatases (RPTPs) have been shown to play key roles in regulating axon guidance and synaptogenesis. HmLAR2, one of two closely related LAR-like RPTPs in the embryonic leech, is expressed in a few central neurons and in a unique segmentally-iterated peripheral cell, the comb cell (CC). Here...

journal_title：Developmental biology

authors： Baker MW,Peterson SM,Macagno ER

更新日期：2008-08-01 00:00:00

abstract：:The basic helix-loop-helix transcription factor Twist1 plays an essential role in mesenchymal cell populations during embryonic development and in pathological disease. Remodeling of the cardiac outflow tract (OFT) into the functionally separate aortic arch and pulmonary trunk is dependent upon the dynamic, coordinate...

journal_title：Developmental biology

authors： Vincentz JW,Barnes RM,Rodgers R,Firulli BA,Conway SJ,Firulli AB

更新日期：2008-08-01 00:00:00

abstract：:Although the formation and maintenance of epithelial tubes are essential for the viability of multicellular organisms, our understanding of the molecular and cellular events coordinating tubulogenesis is relatively limited. Here, we focus on the activities of Ribbon, a novel BTB-domain containing nuclear protein, in t...

journal_title：Developmental biology

authors： Kerman BE,Cheshire AM,Myat MM,Andrew DJ

更新日期：2008-08-01 00:00:00